Parabens Free

People are becoming increasingly aware of the ingredients that they are eating, using and placing on their skin. This is all for good reason. Not all ingredients are good for you. “Organic” may be more than just a buzz word used by marketing gurus afterall. One may encounter the term “Paraben” free in the market on labels and packaging. But what are Parabens and why is there a focus on “Paraben Free”?

What are Parabens?

Parabens are a group of artificial preservatives used in food, cosmetic and body care products since the 1920s. These compounds are made from para-hydroxybenzoic acid (PHBA) that is found commonly in nature. These preservatives were added as a cost effective option for increasing shelf life of products. Because food, cosmetics and body care products contain biodegradable ingredients, the addition of parabens limited growth of harmful bacteria and mold. Their antimicrobial properties are most effective against fungi and gram positive bacteria.

Parabens are lipophilic molecules, meaning that they are easily absorbed through the skin into fat tissue around the body. Recent scientific studies suggest that parabens disrupt the hormonal balance (endocrine disruption) in the body especially in estrogen related pathways. These studies suggest that this could result in harm to fertility, reproductive organs, affect birth outcomes and increase the risk of cancer.

Moreover, studies have detected parabens in nearly all urine samples taken from adults in the U.S., regardless of demographics (Ye 2006). Given the endocrine disruption capacity and documented reproductive harm, coupled with the potential for repeated lifelong exposure, it is clear that parabens should not be used in personal care or cosmetic products.

What Products Contain Parabens?

Parabens are found in a wide variety of products that people use everyday. Moisturizers, face and skin cleaners, sunscreens, deodorants, shaving gels, toothpastes, shampoos, conditioners, makeup and many other products contain parabens. They are absorbed into the body through the skin, metabolized and then excreted in urine and bile (Soni 2005). However, daily use of a product or multiple products containing parabens results in direct and continuous exposure, as indicated by nearly ubiquitous detection in biomonitoring surveys.

Personal care products are the greatest contributors to paraben exposure, as seen in studies comparing paraben levels in the bodies of women, men, adolescents and children who regularly use cosmetics and those who do not. Adolescent girls who wear makeup every day had 20 times the levels of propylparaben in their urine compared to those who never or rarely wear makeup (Berger 2018). The use of body and face lotions, hair products, sunscreens and makeup have all been predictors of and correlated with remarkably increased levels of urinary parabens (Sahki 2018, Nassan 2017, Braun 2014 and Fisher 2017).

Food and Beverages contain Parabens too

People can also be exposed to parabens by eating foods and beverages that do not just contain parabens but are also preserved with them. In the 1970s, propylparaben was designated as “generally recognized as safe” for addition to food up to 0.1 percent (CDC 2016). But this safety label may be outdated, given the recent studies that point to health effects associated with parabens.

Types of Parabens

Cosmetics typically contain mixtures of different types of parabens. The most commonly used six types are methyl-, ethyl-, propyl-, isopropyl-, butyl- and isobutylparaben. The so-called shorter-chain parabens, methyl- and ethyl-, are commonly used in combination, whereas butylparaben is often used alone. The longer-chain parabens, propyl- and butyl-, are linked to stronger estrogenic activity (Blair 2000 and Vo 2010). The branched structure has been shown to increase estrogenic activity as well as sensitization potency (Darbre 2002 and Sonnenburg 2015).

Health Effects

Endocrine disruption and reproductive harm

Parabens act like the hormone estrogen in the body and disrupt the normal function of hormone systems affecting male and female reproductive system functioning, reproductive development, fertility and birth outcomes. Parabens can also interfere with the production of hormones. The U.N. Environment Programme has identified parabens as a group, including propyl- and butylparaben, as endocrine-disrupting chemicals or potential endocrine-disrupting chemicals (U.N. Environment 2017). The Danish Centre on Endocrine Disruptors has also identified butyl- and isobutylparaben as endocrine disruptors (Danish Centre on Endocrine Disrupters 2018).

Scientific studies have reported the estrogenic activity of parabens (Byford 2002, Kim 2011, Vo 2011, Vo 2010). The estrogenic potency increases with the length of the paraben (Blair 2000 and Vo 2010) and branching side chains also increase estrogenic activity, as observed in in vitro and in vivo studies (Darbre 2002).

In animal studies, propyl-, isopropyl- and isobutylparabens disrupted hormone signals, and exposure to all these parabens and butylparaben harmed female reproductive development (Vo 2010). In another animal study, developmental exposure to butylparaben harmed male reproduction by decreasing sperm production and lowering testosterone levels (Zhang 2014). Boberg (2016) found exposure to butylparaben during development in rats harmed both female and male reproductive systems. Sperm count was decreased at very low doses of only 10 mg/kg of body weight per day.

In human studies, researchers from the Harvard T.H. Chan School of Public Health found decreased fertility was associated with urinary propylparaben (Smith 2013). Another human study linked butylparaben and total urinary paraben levels with decreased fertility, as indicated by decreased menstrual cycle length (Nishihama 2016). Butylparaben levels in the mother’s urine and levels in cord blood were associated with increased odds of pre-term birth and decreased birth weight (Geer 2017).

Endocrine disruption and cancer

Scientists are concerned about the exposure to environmental estrogens and how they may contribute to the risk of cancer, particularly breast cancer in women. Propylparaben can alter the expression of genes, including those in breast cancer cells (Wróbel 2014), and accelerate the growth of breast cancer cells (Okubo 2001). A recent University of California-Berkeley study found that low doses of butylparaben, previously not considered harmful, worked in conjunction with other cell receptors to switch on cancer genes and increased the growth of breast cancer cells (Pan 2016).

Skin irritation

The skin can become sensitized to products containing parabens, which results in irritation (CIR 2006). The potency of sensitization has been shown to be related to the side-chain length of parabens (Sonnenburg 2015).

Parabens in the Body

In National Health and Nutrition Examinations Surveys, the Centers for Disease Control and Prevention, or CDC, detected propylparaben in greater than 92 percent of Americans tested, and butylparaben in about 50 percent of those tested (Calafat 2010). These results were similar to levels measured in adolescent girls in the 2016 HERMOSA intervention study (Harley 2016). Following just a three-day intervention, when the girls used products without parabens, propylparaben levels in urine dropped by about 45 percent.

Parabens have been detected in infants (Calafat 2009) and older children (Calafat 2010), as well as adults, including pregnant women (Smith 2013). Therefore, exposure may begin in early life stages and be continuous. Parabens may also bioaccumulate in the body over time in fat tissue, as metabolites of parabens measured in fat were correlated with age (Aracho-Cordón 2018 and Wang 2015).

Environmental Effects

Parabens are linked to ecological harm, as low levels of butylparaben can kill coral, according to laboratory tests (Danaovaro 2008). Parabens have been detected in surface waters, fish and sediments (Haman 2015). When parabens are combined with chlorinated tap water, a number of chlorinated paraben byproducts can form (Canosa 2006). Little is known about the toxicity of these byproducts, which may be more persistent (Haman 2015).


Artacho-Cordón FFernández MFFrederiksen HIribarne-Durán LMJiménez-Díaz IVela-Soria FAndersson AMMartin-Olmedo PPeinado FMOlea NArrebola JP. 2018. Environmental phenols and parabens in adipose tissue from hospitalized adults in Southern Spain. Environ Int. 119:203-211.

Berger KP, Kogut KR, Bradman A, She J, Gavin Q, Zahedi R, Parra KL, Harley KG. 2018. Personal care product use as a predictor of urinary concentrations of certain phthalates, parabens, and phenols in the HERMOSA study. J Expo Sci Environ Epidemiol 29(1):21-32.

Blair RMFang HBranham WSHass BSDial SLMoland CLTong WShi LPerkins RSheehan DM. 2000. The estrogen receptor relative binding affinities of 188 natural and xenochemicals: structural diversity of ligands. Toxicol Sci. 54(1):138-53.

Boberg J, Axelstad M, Svingen T, Mandrup K, Christiansen A, Vinggaard AM, Hass U. 2016. Multiple Endocrine Disrupting Effects in Rats Perinatally Exposed to Butylparaben. Toxicological Sciences 152(1) 244-256.

Braun JM, Just AC, Williams PL, Smith KW, Calafat AM, Hauser R. 2014. Personal care product use and urinary phthalate metabolite and paraben concentrations during pregnancy among women from a fertility clinic. J Expo Sci Environ Epidemiol 24(5):459-66.

Byford JR, Shaw LE, Drew MG, Pope GS, Sauer MJ, Darbre PD. 2002. Oestrogenic activity of parabens in MCF7 human breast cancer cells. The Journal of steroid biochemistry and molecular biology 80(1): 49-60.

Calafat AM, Ye X, Wong LY, Bishop AM, Needham LL. 2010. Urinary concentrations of four parabens in the U.S. population: NHANES 2005-2006. Environ Health Perspect. 118(5):679-85.

Calafat AM, Weuve J, Ye X, Jia LT, Hu H, Ringer S, et al. 2009. Exposure to bisphenol A and other phenols in neonatal intensive care unit premature infants. Environ Health Perspect 117 (4):639–644.

Canosa P, Rodriguez I, Rubi E, Negreira N, Cela R. 2006. Formation of halogenated by-products of parabens in chlorinated water. Analytica chimica acta 575(1): 106-113.

CDC National Biomonitoring Program. Biomonitoring Summary, Parabens. 2016.

CIR (Cosmetics Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington, DC: Cosmetics Ingredient


Danish Centre on Endocrine Disrupters. 2018. List of Endocrine Disrupting Chemicals.

Danovaro R, Bongiorni L, Corinaldesi C, Giovannelli D, Damiani E, Astolfi P, et al. 2008. Sunscreens cause coral bleaching by promoting viral infections. Environmental Health Perspectives 116(4): 441-447.

Darbre PD, Byford JR, Shaw LE, Horton RA, Pope GS, Sauer MJ. 2002. Oestrogenic activity of isobutylparaben in vitro and in vivo. J Appl Toxicol 22(4): 219-226.

EDF 2019. Who is promising what on home and personal care products in the U.S?

Geer LAPycke BFGWaxenbaum JSherer DMAbulafia OHalden RU. 2017. Association of birth outcomes with fetal exposure to parabens, triclosan and triclocarban in an immigrant population in Brooklyn, New York. J Hazard Mater 323(Pt A):177-183.

Haman C1Dauchy XRosin CMunoz JF. 2015. Occurrence, fate and behavior of parabens in aquatic environments: a review. Water Res. 68:1-11.

Harley KG, Kogut K, Madrigal DS, Cardenas M, Vera IA, Meza-Alfaro G, She J, Gavin Q, Zahedi R, Bradman A, Eskenazi B, Parra KL. 2016. Reducing phthalate, paraben, and phenol exposure from personal care products in adolescent girls: findings from the HERMOSA Intervention Study. Environ Health Perspect 124:1600–1607.

Kim TS, Kim CY, Lee HK, Kang IH, Kim MG, Jung KK, Kwon YK, Nam HS, Hong SK, Kim HS, Yoon HJ, Rhee GS. 2011. Estrogenic Activity of Persistent Organic Pollutants and Parabens Based on the Stably Transfected Human Estrogen Receptor-α Transcriptional Activation Assay (OECD TG 455). Toxicol Res. 27(3):181-4.

Nassan FL, Coull BA, Gaskins AJ, Williams MA, Skakkebaek NE, Ford JB, Ye X, Calafat AM, Braun JM, Hauser R. 2017. Personal Care Product Use in Men and Urinary Concentrations of Select Phthalate Metabolites and Parabens: Results from the Environment and Reproductive Health (EARTH) Study. Environ Health Perspect 125(8):087012.

Nishihama YYoshinaga JIida AKonishi SImai HYoneyama MNakajima DShiraishi H. 2016. Reprod Toxicol 63:107-13.

Okubo T, Yokoyama Y, Kano K, Kano I. 2001. ER-dependent estrogenic activity of parabens assessed by proliferation of human breast cancer MCF-7 cells and expression of ERalpha and PR. Food Chem Toxicol 39(12):1225-32.

Pan S, Yuan C, Tagmount A, et al. 2015. Parabens and Human Epidermal Growth Factor Receptor Ligand Cross-Talk in Breast Cancer Cells. Environ Health Perspect 124(5):563–569.

Pugazhendhi D, Sadler AJ, Darbre PD. 2007. Comparison of the global gene expression profiles produced by methylparaben, n-butylparaben and 17beta-oestradiol in MCF7 human breast cancer cells. J Appl Toxicol 27(1): 67-77.

Sakhi AK, Sabaredzovic A, Papadopoulou E, Cequier E, Thomsen C. 2018. Levels, variability and determinants of environmental phenols in pairs of Norwegian mothers and children. Environ Int 114: 242-251.

Scientific Committee on Consumer Safety. European Commission. Opinion on Parabens. 2013.

Smith KW, Souter I, Dimitriadis I, Ehrlich S, Williams PL, Calafat AM, Hauser R. 2013. Urinary paraben concentrations and ovarian aging among women from a fertility center. Environ Health Perspect 121(11-12):1299-305.

Soni MG, Carabin IG, Burdock GA. 2005. Safety assessment of esters of p-hydroxybenzoic acid (parabens). Food Chem Toxicol 43 (7): 985-1015.

Sonnenburg ASchreiner MStahlmann R. 2015. Assessment of the sensitizing potency of preservatives with chance of skin contact by the loose-fit coculture-based sensitization assay (LCSA). Arch Toxicol 89(12):2339-44.

United Nations Environment Program. International Panel on Chemical Pollution. 2017. Worldwide initiatives to identify endocrine disrupting chemicals (EDCs) and potential EDCs.

Vo TT, Yoo YM, Choi KC, Jeung EB. 2010. Potential estrogenic effect(s) of parabens at the prepubertal stage of a postnatal female rat model. Reprod Toxicol 29(3):306-316.

Vo TT, Jung EM, Choi KC, Yu FH, Jeung EB. 2011. Estrogen receptor α is involved in the induction of Calbindin-D(9k) and progesterone receptor by parabens in GH3 cells: a biomarker gene for screening xenoestrogens. Steroids 76(7):675-81.

Wang L, Asimakopoulos AG, Kannan K. 2015. Accumulation of 19 environmental phenolic and xenobiotic heterocyclic aromatic compounds in human adipose tissue. Environ Int 78:45-50.

Wróbel AM, Gregoraszczuk EL. 2014. Actions of methyl-, propyl- and butylparaben on estrogen receptor-α and -β and the progesterone receptor in MCF-7 cancer cells and non-cancerous MCF-10A cells. Toxicol Lett 230(3):375-381.

Ye X, Bishop AM, Reidy JA, Needham LL, Calafat AM. 2006. Parabens as urinary biomarkers of exposure in humans. Environmental Health Perspectives 114(12): 1843-1846.

Zhang L, Dong L, Ding S, Qiao P, Wang C, Zhang M, Zhang L, Du Q, Li Y, Tang N, and et al. 2014. Effects of n-butylparaben on steroidogenesis and spermatogenesis through changed E(2) levels in male rat offspring. Environ. Toxicol. Pharmacol 37:705-717.